Time for a prehospital-modified sequential organ failure assessment score: An ambulance–Based cohort study

To adapt the Sequential Organ Failure Assessment (SOFA) score to fit prehospital care needs; do that, SOFA was modified by replacing platelets and bilirubin, lactate, tested this (mSOFA) in its prognostic capacity assess mortality-risk at 2 days since first Emergency Medical Service (EMS) contact. Prospective, multicentric, EMS-delivery, ambulance-based, pragmatic cohort study of adults with acute diseases, referred two tertiary hospitals (Spain), between January 1st December 31st, 2020. The discriminative power predictive variable assessed through a prediction model trained using derivation evaluated area under curve (AUC) receiver operating characteristic (ROC) on validation cohort. A total 1114 participants comprised separated cohorts recruited from 15 ambulance stations. 2-day mortality rate (from any cause) 5.9% (66 cases). validity mSOFA calculation AUC ROC cohort, resulting an 0.946 (95% CI, 0.913–0.978, p < .001), positive likelihood ratio 23.3 0.32–46.2). Scoring systems are now reality care, assesses multiorgan dysfunction simple agile manner either bedside or en route. Patients disease greater than 6 points transferred high priority EMS represent early group. Trial registration: ISRCTN48326533, Registered Octuber 312,019, Prospectively registered (doi:https://doi.org/10.1186/ISRCTN48326533).